University of Cambridge  

 Genetics and Infection Laboratory 

              
   
Introduction

Publications and Reviews:



Selected Publications:

2007 - 2006 - 2005 - 2004 - 2003 - 2002 - 2001 - 2000 - 1999 - 1998 - 1997 - 1996 - 1995




2007

Jamieson, S.E., Miller, E.N., Peacock, C.S., Fakiola, M., Jeronimo, S., Wilson, M.E., Bales, A., Shaw, M-A., Silveira, F., Shaw, J.J. and Blackwell, J.M. (2007) Genome-wide scan for visceral leishmaniasis susceptibility genes in Brazilians. Genes and Immunity, 8, 84-90. (Epub: Nov 23, 2006). indicates equal contributions. PubMed

Salih, M.A., Ibrahim, M.E., Blackwell, J.M., Miller, E.N., Khalil, E.A.G., ElHassan, A.M., Musa, A.M. and Mohamed, H.S. (2007) IFNG and IFNGR1 gene polymorphisms and susceptibility to post kala-azar dermal leishmaniasis in Sudan. Genes and Immunity, 8, 75-78. (Epub: Nov 30, 2006). PubMed

Stober, C.B. Lange, U., Roberts, M.T.M., Alcami, A. and Blackwell, J.M. (2007) Heterologous prime-boosting with DNA and modified vaccinia virus Anakara expressing tryparedoxin peroxidase promotes long-term memory against Leishmania major in susceptible BALB/c mice. Infection and Immunity, 75, 852-860. (Epub: Nov 13, 2006). PubMed

Miller, E.N., Fadl, M., Mohamed, H.S., El Zein, A., Jamieson, S.E., Cordell, H.J., Peacock, C.S., Fakiola, M., Raju, M., Khalil, E.A., Elhassan, A., Musa, A.M., Ibrahim, M.E. and Blackwell, J.M. (2007) Y chromosome lineages tag village-specific genes on chromosomes 1p22 and 6q27 that control visceral leishmaniasis in The Sudan. PLoS Genetics, in press. (Epub: Mar 19, 2007; doi:10.1371/journal.pgen.0030071.eor) indicates equal contributions.

Bayele, H.K., Peyssonnaux, C., Giatromanolaki, A., Arrais-Silva, W.A., Collins, H., Giorgio, S., Koukourakis, M., Nizet, V., Blackwell, J.M., Johnson, R.S. and Srai, S.K.S. (2007) HIF-1α regulates heritable variation in SLC11A1 expression phenotypes relevant to innate immunity and inflammation. Blood, under revision.

Johnson, C.M., Traherne, J.A, Jamieson, S.E., Tremelling, M. Parkes, M., Blackwell, J.M. and Trowsdale, J. (2007) Analysis of the BTNL2 truncating splice site mutation in tuberculosis, leprosy and Crohn's disease. Tissue Antigens, in press.

Stober, C.B., Brode, S., White, J.K., Popoff, J-F., Blackwell, J.M. (2007) Slc11a1 (formerly Nramp1) is expressed in dendritic cells and influences MHC class II expression and antigen presenting cell function. Infection and Immunity, submitted.

Jeronimo, S.M.B., Holst, A.K.B., Jamieson, S.E., Francis, R., Martins, D.R.A., Ettinger, N., Nascimento, E.Y., Miller, E.N., Murray, J.C., Duggal, P., Beaty, T., Blackwell, J.M. and Wilson, M.E. (2007) Genes at human chromosome 5q31.1 regulate delayed type hypersensitivity responses associated with Leishmania chagasi infection. Genes and Immunity, submitted. indicates equal contributions.

Jamieson, S.E., de Roubaix, L-A, Tan, H.K., Cortina-Borja, M., Mui, E. Mack, D., Kirisitsand , M., Miller, E.N., Cordell, H.J., Hargrave, A., Kasza, K., Karrison, T., [middle author list EMSCOT and USA to be determined], Petersen, E., McLeod, R., Gilbert, R.E. and Blackwell , J.M. - for the European Multicentre Study on Congenital Toxoplasmosis (EMSCOT) and the other members of the U.S. Toxoplasmosis Study Group (NCCCTS). (2007) COL2A1 and ABCA4 are epigenetically modified and associated with congenital toxoplasmosis. Manuscript to submit. indicates equal contributions

Techau, M.E., Valdez-Taubas, J., Popoff, J-F., Francis, R., Seaman, M. and Blackwell, J.M. (2007) Evolution of antiport activity in Slc11a family members. Molecular and Cellular Biology, submitted. indicates equal contributions.



2006

Stober, C.B. Lange, U., Roberts, M.T.M., Gilmartin, B., Francis, R., Almeida, R., Peacock, C.S., McCann, S. and Blackwell, J.M. (2006) From genome to vaccines for leishmaniasis: Screening 100 novel vaccine candidates against murine Leishmania major infection. Vaccine, 24, 2602-2616. PubMed

Wheeler, E., Miller, E.N., Peacock, C.S., Donaldson, I.J., Shaw, M.-A., Jamieson, S.E., Blackwell, J.M. and Cordell, H.J. (2006) Genome-wide scan for loci influencing quantitative immune response traits in the Belem Family Study: comparison of methods and summary of results. Annals of Human Genetics, 70, 78-97. PubMed

Castellucci, L., Guimaraes, L., Lessa, M., Lessa, H., Ribeiro, S., Reale, J., Oliveira, J., Henezes, E., Hagalliaes, A., Noronha, E., Wilson, M.E., Duggal, P., Beatty, T., Jeronimo, S., Jamieson, S.E., Blackwell, J.M., de Jesus, A. and Carvalho, E. (2006) IL6 -174 G/C Promoter Polymorphism Influences Susceptibility to Mucosal but Not Localized Cutaneous Leishmaniasis in Brazil. Journal of Infectious Diseases, 194, 519-527. PubMed

Burgner, D., Jamieson S.E. and Blackwell, J.M. (2006) Genetic susceptibility to infectious diseases: big is beautiful and big will be even better? Lancet Infectious Diseases, Lancet Infectious Diseases, 6, 653-663. PubMed



2005

Awomoyi, A.A., Charurat, M., Marchant, A., E.N. Miller, Blackwell, J.M., McAdam, K.P.W.J. and Newport, M.J. (2005) Polymorphism in IL1β: IL1β-511 association with tuberculosis and decreased lipopolysaccharide-induced IL-1β in IFN-γ primed ex-vivo whole blood assay. Journal of Endocrine Research, 11, 281-286. PubMed

Mahdi, M., Ibrahim, M.E., Elamin, E.M., Melville, S.E., Musa, A.M., Blackwell, J.M., Mukhtar, M.M. and Elhassan, A.M. (2005) Sudanese mucosal leishmaniasis: Isolation of a parasite within the Leishmania donovani complex that differs genotypically from L. donovani causing classical visceral leishmaniasis. Infection, Genetics and Evolution, 5, 29-39. PubMed

White, J.K., Mastroeni, P., Popoff, J-F., and Blackwell, J.M. (2005) Slc11a1-mediated resistance to Salmonella typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase activity or phagocyte oxidase activity. Journal of Leukocyte Biology, 77, 311-320. PubMed

Jamieson, S.E., White, J.K., Pask, R., Smith, A.N., Brayne, C., Evans, J.G., Xuereb, J., Cairns, N.J., Rubinsztein, D.C. and Blackwell, J.M. (2005) Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease. Neuroscience Letters, 374, 124-125. PubMed

Dubaniewicz, A., Jamieson, S.E., Fakiola, M., Dubaniewicz, N., Miller, E.N. and Blackwell, J.M. (2005) Association between SLC11A1 (formerly NRAMP1) and the risk of sarcoidosis in Poland. European Journal of Human Genetics, 13, 829-834. PubMed

Stober, C.B. Lange, U., Roberts, M.T.M., Alcami, A. and Blackwell, J.M. (2005) IL-10 from CD4+CD25+ regulatory T cells determines vaccine efficacy in murine Leishmania major infection. Journal of Immunology, 175, 2517-2524. PubMed

Roberts, M.T.M., Stober, C.B., McKenzie, A.N. and Blackwell, J.M. (2005) IL-4 and IL-10 collude in vaccine failure for novel exacerbatory antigens in murine Leishmania major infection. Infection and Immunity, 73, 7620-7628. PubMed

Ivens, A.C, Peacock, C.S., Worthey, E.A., Murphy, L., Aggarwal, G., Berriman, M., Sisk, E., Hertzfowler, C., Quail, M.A., Harris, D., Rajandream, M-A., Davies, R.M., Aert, R., Andersson, B., Anupama, A., Attipoe, P., Bason, N., Bauser, C., Beck, A., Beverley, S.M., Bianchettin, G., Borzym, K., Bothe, G., Bruschi, C.V., Collins, M., Cadag, E., Ciarloni, L., Clayton, C., Coulson, R.M.R., Cronin, A., Cruz, A.C., r De Gaudenzi, J., Dobson, D.E., Duesterhoeft, A., Fazelina, G., Fosker, N., Frasch, A.C., Fraser, A., Fuchs, M., Gabel, C., Goble, C., Goffeau, A., Hilbert, H., Horn, D., Huang, Y., Klages, S., Knights, A., Kube, M., Larke, N., Litvin, L., Lord, A., Louie, T., Marra, M., Masuy, D., Matthews, K., Michaeli, S., Mottram, J.C., Mueller-Auer, S., Munden, H., Nelson, S., Nilsson, D., Norbertczak, H., Oliver, K., O'Neill, S., Pentony, M., Pohl, T.M., Price, C., Purnelle, B., Rabbinowitsch, E., Reinhardt, R., Rieger, M., Rinta, J., Robben, J., Robertson, L., Ruiz, J., Rutter, S., Saunders, D., Schaefer, M., Schein, J., Schwartz, D.C., Seeger, K., Seyler, A., Sharp, S., Shin, H., Sivam, D., Squares, R., Squares, S., Tosato, V., Tram, A-N., Vogt, C., Volckaert, G., Wambutt, R., Warren, T., Wedler, H., Woodward, J., Zhou, S., Zimmermann, W., Smith, D.F., Blackwell, J.M., Stuart, K.D., Barrell, B. and Myler, P.J. (2005) The genome of the kinetoplastid parasite, Leishmania major. Science, 309, 436-442. PubMed



2004

White, J.K., Stewart, A., Popoff, J-F., Wilson, S. and Blackwell, J.M. (2004) Incomplete glycosylation and defective intracellular targeting of mutant Slc11a1. Biochemical Journal, 382, 811-819.PubMed

Lange, U., Mastroeni, P., Blackwell, J.M., and Stober, C.B. (2004) Boasting with Salmonella-encoded antigen following DNA priming biases towards a type 1 immune response. Infection and Immunity, 72, 4924-4928.PubMed

Miller, E.N., Jamieson, S., Joberty, C., Fakiola, M., Hudson, D., Peacock, C.S., Cordell, H., Shaw, M-A., Lins-Lainson, Z., Shaw, J.J., Ramos, F., Silveira, F. and Blackwell, J.M. (2004) Genome-wide scans for leprosy and tuberculosis susceptiblity genes in Brazilians. Genes and Immunity, 5, 63-67.PubMed

Mohamed, H., Ibrahim, M.E., Miller, E.N., White, J.K., Cordell, H.J., Howson, J.M.M., Peacock, C.S. Khalil, E.A.G., El Hassan, A.M. and Blackwell, J.M.. (2004). SLC11A1 (formerly NRAMP1) and susceptibility to visceral leishmaniasis in The Sudan. European Journal of Human Genetics, 12, 63-74.PubMed

Jamieson, S., Miller, E.N., Black, G.F., Peacock, C.S., Cordell, H.J., Howson, J.M.M., Shaw, M-A., Burgner, D., Xu, W., Lins-Lainson, Z., Shaw, J.J., Ramos, F., Silveira, F., and Blackwell, J.M. (2004) Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to leprosy and tuberculosis in Brazilians. Genes and Immunity, 5, 46-57.PubMed

Sibthorpe, D., Baker, A-M., Gilmartin, B.J, Blackwell, J.M. and White, J.K. (2004) Comparative analysis of two Slc11a (Nramp) loci in Fugu rubripes. DNA and Cell Biology, 23, 45-58.PubMed

Hoal, E.G., Lewis, L-A., Tanzer, F., Rossouw, M., Victor, T., Blackwell, J.M., Hillerman, R., Beyers, N., van Helden, P.D. (2004) SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are associated with susceptibility to tuberculosis in a high incidence community in South Africa. International Journal of Tuberculosis and Lung Disease, 8, 1464-1471.PubMed

Weir, R.E., Black, G.F., Dockrell , H.M., Fine, P.E.M., Chaguluka, S.D., Stenson, S., King, E., Warndorff, D.K., Ngwira, B., Crampin, A.C., Mwaungulu, L., Sichali, L., Floyd, S., Bliss, L., Branson, K., Jarman, E., Donovan, L. and Blackwell, J.M. (2004) Mycobacterial PPDs stimulate innate immunity: Malawians show enhanced TNFα, IL-1β and IL-10 responses compared to UK adolescents. Infection and Immunity, 72, 1807-1811.PubMed

Awomoyi, A.A., Nejentsev, S., Richardson, A., Hull,, J., Koch, O., Todd, J.A., McAdam, K.P.W.J., Blackwell, J.M., Kwiatkowski, D. and Newport, M.J. (2004) No association between interferon-{gamma} receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample. Thorax, 59, 291-294.PubMed

Stockton, J.C., Howson, J.M.M., Awomoyi, A.A., McAdam, K.P., Blackwell, J.M. and Newport, M.J. (2004) Polymorphism in NOD2, Crohns disease and susceptibility to pulmonary tuberculosis. FEMS Immunology and Medical Microbiology, 41, 157-160.PubMed

Almeida, R., Gilmartin, B., McCann, S., Norrish, A., Ivens, A., Lawson, D., Levick, M., Smith, D., Dyall, S.D., Vetrie, D., Freeman, T., Coulson, R., Sampaio, I., Schneider, H. and Blackwell, J.M. (2004) Expression profiling of the Leishmania life cycle: cDNA arrays identify developmentally regulated genes present but not annotated in the genome. Molecular and Biochemical Parasitology, 136, 87-100.PubMed



2003

Mohamed, H.S., Ibrahim, M.E., Miller, E.N., Peacock, C.S., Khalil, E.A.G., Cordell, H.J., Howson, J.M.M., El Hassan, A.M., Bereir, R.E.H. and Blackwell, J.M. (2003) Genetic susceptibility to visceral leishmaniasis in The Sudan: linkage and association with IL4 and IFNGR1. Genes and Immunity, 4, 351-355. PubMed

Bereir, R.E.H., Mohamed, H.S., Seielstad, M., El Hassan, A.M., Khalil, E.A.G., Peacock, C.S., Blackwell, J.M. and Ibrahim, M.E. (2003) Allele frequency and genotype distribution of polymorphisms within disease-related genes is influenced by ethnic population sub-structuring in Sudan. Genetica, 119, 57-63.PubMed

Newport, M.J., Awomoyi, A.A. and Blackwell, J.M. (2003) Polymorphism in the interferon-gamma receptor 1 gene and susceptibilitiy to tuberculosis in The Gambia. Scandinavian Journal of Immunology, 58, 383-385.PubMed



2002

Mulero, V., Searle, S., Blackwell, J.M. and Brock, J.H. (2002) Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytosis, but not by transferrin receptor mediated, iron uptake. Biochemical Journal, 363, 89-94.PubMed

Black, G.F., Weir, R.E., Floyd, S., Bliss, S., Warndorff, D.K., Crampin, A.C., Ngwira, B., Sichali, L., Nazareth, B., Blackwell, J.M., Branson, K., Chaguluka, S.D., Donovan, L., Jarman, E., King, E., Fine, P.E.M. and Dockrell, H.M. (2002) BCG-induced increase in interferon-? responsiveness to mycobacterial antigens: a correlate of protection against human tuberculosis. Lancet, 359, 1393-1401.PubMed

Alm, J.S., Sanjeevi, C.B., Miller, E.N., Dabadghao, P., Lilja, G., Pershagen, G., Blackwell, J.M. and Scheynius, A. (2002) Atopy in children in relation to BCG vaccination and genetic polymoprhisms at SLC11A1 (formerly NRAMP1) and D2S1471. Genes and Immunity, 3,71-77.PubMed

Peacock, C. S., Sanjeevi, C.B., Shaw, M.-A., Collins, A., Campbell, R.D., March, R., Silveira, F., Costa, J., Coste, C.H., Nascimento, M.D., Siddiqui, R., Shaw, J.J. and Blackwell, J.M. (2002) Genetic analysis of multicase families of visceral leishmaniasis in northeastern Brazil: No major role for class II and class III regions of HLA. Genes and Immunity, 3, 350-358.PubMed

Awomoyi, A.A., Marchant, A., Howson, J.M.M., McAdam, K.P.W.J., Blackwell, J.M. and Newport, M.J. (2002) Interleukin-10, polymorphism in SLC11A1 (Formerly NRAMP1) and susceptibility to tuberculosis. Journal of Infectious Diseases, 186, 18081814.PubMed

2001

Peacock, C.S., Collins, A., Shaw, M.-A., Silveira, F., Robinson, R.L., Costa, J., Coste, C.H., Nascimento, M.D., Siddiqui, R., Shaw, J.J. and Blackwell, J.M. (2001) Genetic epidemiology of visceral leishmaniasis in Northern Brazil. Genetic Epidemiology, 20,:383-96. PubMed

Goswami, T., Bhattacharjee, A., Babal, P., Searle, S., Moore, E., Li, M. and Blackwell, J.M. (2001) Natural resistance associated macrophage protein 1 is an H+/bivalent cation antiporter. Biochemical Journal, 354, 511-519. PubMed

Shaw, M-A., Donaldson, I.J., Collin, A., Peacock, C.S., Lins-Lainson, Z., Shaw, J.J., Ramos, F., Silveira, F. and Blackwell, J.M. (2001) Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes. Genes and Immunity, 2, 196-204. PubMed

Evans, C.A.W., Harbuz, M.S., Ostenfeld, T., Norrish, A. and Blackwell, J.M. (2001) Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress. Neurogenetics, 3, 69-78. PubMed

Dunstan, S.J., Stephens, H.A., Blackwell, J.M., Duc, C.M., Lanh, M.N., Phuong, C, Luxemburger, C., Wain, J., Cam, L.H., Hien, T.T., Farrar, J. and Dougan, J. (2001) Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam. Journal of Infectious Diseases, 183, 261-268. PubMed

Dunstan, S.J., Peacock, C.S., Duc, C.C., Lanh, M.N., Phuong, C., Luxemburger, C., Wain, J., Vo An Ho, V.A., Hien, T.T. , Dougan, G., Farrar, J. and Blackwell, J.M. (2001). Typhoid fever and genetic polymorphisms at the Natural Resistance-Associated Macrophage Protein 1. Journal of Infectious Diseases, 183,1156-60. PubMed

Black, G.F., Fine, P.E.M., Warndorff, D.K., Floyd, S., Weir, R.E., Blackwell, J.M., Bliss, L., Sichali, L., Mwaungulu, L., Chaguluka, S., Jarman, E., Ngwira, B. and Dockrell, H.M. (2001) Correlation between IFN-g and skin test responsiveness to Mycobacterium tuberculosis PPD in healthy, non-BCG-vaccinated young adults in Northern Malawi. International Journal of Tuberculosis and Lung Disease, 5, :664-72. PubMed


2000
Cabrera, M., Blackwell, J.M., Castes, M., Trujillo, D., Convit, J. and Shaw, M-A. (2000) Immunotherapy with BCG plus heat killed Leishmania induces a Th1-like response in American cutaneous leishmaniasis. Parasite Immunology, 22, 73-79. PubMed

Matthews, D.J., Emson, C.L., McKenzie, G.J., Jolin, H.E., Blackwell, J.M. and McKenzie, A.N.J. (2000). Interleukin-13 is a susceptibility factor for Leishmania major infection. Journal of Immunology 2000 Feb 1;164(3):1458-62.PubMed

Nikitina, G.M., Peacock, C.S., Hjelmstrom, P., Hallmans, G., Wiklund, F., Lenner, P., Blackell, J.M., Dillner, J. and Sanjeevi, C.B. (2000) Tumor necrosis factor a-11 and DR15-DQ6 (B*0602) haplotype increase the risk for cervical intraepithelial neoplasia in human papillomavirus 16 seropositive women in Northern Sweden. Cancer Epidemiol Biomarkers Prev. 9, 1067-70. PubMed

Sanjeevi, C.B., Miller, E.N., Dabadghao, P., Rumba, I., Shtuvere, A., Denisova, A. and Blackwell, J.M. (2000) Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis. Arthritis and Rheumatism, 2000 Jun;43(6):1397-404 . PubMed

1999
Blackwell, J.M. (1999). Tumour necrosis factor polymorphism and mucocutaneous leishmaniasis. Parasitology Today, 15, 73-75. PubMed

Blackwell, J.M., Black, G.F., Sharples, C., Soo, S-S., Peacock, C.S. and Miller, E.N. (1999). Roles of Nramp1, HLA, and a gene(s) in allelic association with IL4, in determining T helper subset differentiation. Microbes and Infection, 1, 95-102. PubMed

Blackwell, J.M. and Searle, S. (1999). Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg). Immunology Letters, 65, 73-80. PubMed

Ivens, A.C. and Blackwell, J.M. (1999). The Leishmania genome comes of age. Parasitology Today, 15, 225-231. PubMed

Marchant, A., Goetghebuer, T., Ota, M.O., Wolfe, I., Ceesay, S.J., De Groote, D., Corrah, T., Bennett, S., Wheeler, J., Huygen, K., Aaby, P., McAdam, K.P., Newport, M.J. (1999). Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guerin vaccination. Journal of Immunology 163, 2249-2255. PubMed

Melville, S.E., Gerrard, C.S. and Blackwell, J.M. (1999) Multiple causes of size variation in the diploid megabase chromosomes of African trypanosomes. Chromosome Research, 7, 191-203. PubMed

Russell, R., Iribar, M.P., Lambson, B., Brewster, S., Blackwell, J.M., Dye, C. and Ajioka, J.W. (1999) Microsatellite variation in Leishmania (Viannia) braziliensis species complex: Implications for inter- and intra-specific comparison. Molecular and Biochemical Parasitology, 103, 71-77. PubMed

Searle, S. and Blackwell, J.M. (1999). Evidence for a functional repeat polymorphism in the promoter of human NRAMP1 that correlates with infectious versus autoimmune disease susceptibility. Journal of Medical Genetics, 36, 295-299. PubMed

Stacey, K.J. and Blackwell, J.M. (1999). Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major. Infection and Immunity, 67, 3719-3726. PubMed

1998
Bastien, P., Blaineau, C., Britto, C., Dedet, J-P., Dubessay, P., Pages, M., Ravel, C., Wincker, P., Blackwell, J.M., Leech, V., Levick, M., Norrish, A., Ivens, A., Lewis, S., Bagherzadeh, A., Smith, D., Myler, P., Stuart, K., Cruz, A., Ruiz, J.C., Schneider, H., Sampaio, I., Almeida, R., Papadopoulou, B., Shapira, M., Belli, S. & Fasel, N. (The Leishmania Genome Network). (1998) The complete karyotype for Leishmania major Friedlin. Parasitology Today, 14, 301-303.

Hjelmstrom, P., Peacock, C.S., Giscombe, R., Pirskanen, R., Lefvert, A.K., Blackwell, J.M. and Sanjeevi, C.B. (1998) Myasthenia gravis with thymic hyperplasia is associated with polymorphisms in the tumor necrosis factor region. Annals of the New York Academy of Sciences, 841, 368-370. PubMed

Hjelmstrom, P., Peacock, C.S., Giscombe, R., Pirskanen, R., Lefvert, A.K., Blackwell, J.M. and Sanjeevi, C.B. (1998) Polymorphism in tumor necrosis factor genes associated with myasthenia gravis. Journal of Neuroimmunology, 88, 137-143. PubMed

Levick, M.P., Tetaud, E., Fairlamb, A.H. and Blackwell, J.M. (1998). Identification and characterisation of a functional peroxidoxin from Leishmania major. Molecular and Biochemical Parasitology, 96, 125-137. PubMed

Melville, S.E., Leech, V., Gerrard, C.S., Tait, A. and Blackwell, J.M. (1998) The complete molecular karyotype of the housekeeping chromosomes of Trypanosoms brucei and the assignment of chromosome-specific markers. Molecular and Biochemical Parasitology, 94, 155-173. PubMed

Searle, S., Bright, N.A., Roach, T.I.A., Atkinson, P.G.P., Barton, C.H., Meloen, R.H. and Blackwell, J.M. (1998). Localisation of Nramp1 in macrophages: modulation with activation and infection. Journal of Cell Science, 111, 2855-2866. PubMed

Soo S-S., Villarreal-Ramos, B., Anjam Khan, C.M., Hormaeche, C.E. and Blackwell, J.M. (1998). Genetic control of immune response to recombinant antigens carried by attenuated Salmonella typhimurium vaccines: Nramp1 influences T helper subset responses and protection against leishmanial challenge. Infection and Immunity, 66, 1910-1917. PubMed

1997
Atkinson, P.G.P, Blackwell, J.M. and Barton, C.H. (1997) The Nramp1 locus encodes a 65kd IFN-inducible protein in murine macrophages. Biochemical Journal, 325, 779-786. PubMed

Blackwell. J.M., Black, G.F., Peacock, C.S., Miller E.N., Sibthorpe, D., Gnananandha, D., Shaw, J.J., Silveira, F., Lins-Lainson, Z., Ramos, F., Collins, A. and Shaw, M.-A. (1997). Immunogenetics of leishmanial and mycobacterial infections: The Belem Family Study. Philosophical Transactions of the Royal Society B, 352, 1331-1345. PubMed

Lang, T., Prina, E., Sibthorpe, D. and Blackwell, J.M. (1997). Nramp1 transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: Influence on antigen processing and presentation. Infection and Immunity, 65, 380-386. PubMed

Shaw, M.-A., Collins, A., Peacock, C.S., Miller, E.N., Black, G.F., Sibthorpe, D., Lins-Lainson, Z., Shaw, J.J., Ramos, F., Silveira, F. & Blackwell, J.M. (1997) Evidence that genetic susceptibility to Mycobacterium tuberculosis in a Brazilian population is under two-locus oligogenic control: linkage study of the candidate genes NRAMP1 and TNFA. Tubercle and Lung Disease, 78, 35-45. PubMed

Silveira, F.T., Blackwell, J.M., Ishikawa, E.A., Brag, R., Shaw, J.J., Quinnell, R.J., Soong, L., Kima, P., McMahon-Pratt, D., Black, G.F. & Shaw, M.-A. (1997) T cell responses to crude and defined leishmanial antigens in patients from the Lower Amazon region of Brazil infected with different species of Leishmania of the subgenera Leishmania and Viannia. Parasite Immunology, 20, 19-26. PubMed

White, J.K., Auerbach, W., Duyao, M.P., Vonsattel, J.P., Gusella, J.F., Joyner, A.L., MacDonald, M.E. (1997). Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nature Genetics 17, 404-10. PubMed

1996
Levick, M., Blackwell, J.M., Connor, V., Coulson, R.M.R., Miles, A., Smith, H.E., Wan, K-L and Ajioka, J.W. (1996). An expressed sequence tag analysis of a full-length, spliced-leader cDNA library from Leishmania major promastigotes. Molecular and Biochemical Parasitology, 76, 345-348. PubMed

Lewis, L.-A., T. Victor, E. Hoal-van Helden, J. Blackwell, S. Tullett, M. Ehlers, N. Beyers, P. Donald, and P. van Helden. (1996). Identification of a C to T mutation at position -236bp in the human NRAMP1 promoter. Immunogenetics 44, 309-311. PubMed

Newport, M.J., Huxley, C.M., Huston, S., Hawrylowicz, C.M., Oostra, B.A., Williamson, R., Levin, M. (1996). A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. New England Journal of Medicine 335, 1941-1949. PubMed

Shaw, M.-A., Clayton, D., Atkinson, S.E., Williams, H., Miller, N., Sibthorpe, D. and Blackwell, J.M. (1996) Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35. Journal of Medical Genetics, 33, 672-677. PubMed

Wan, K-L, Blackwell, J.M. and Ajioka, J.W. (1996) Toxoplasma gondii tachyzoite expressed sequence tags (ESTs): insight into tachyzoite gene expression. Molecular and Biochemical Parasitology, 75, 179-186. PubMed

1995
Barton, C.H., Whitehead, S.W. and Blackwell, J.M. (1995). Nramp transfection transfers pleiotropic effects associated with Ity/Lsh/Bcg gene activity: respiratory burst and nitric oxide pathways. Molecular Medicine, 1, 267-279. PubMed

Blackwell, J.M., Barton, C.H., White, J.K., Searle, S., Baker, A-M., Williams, H. and Shaw, M-A. (1995). Genomic sequence and organization of human NRAMP: identification and mapping of a promoter region polymorphism. Molecular Medicine, 1, 194-205. PubMed

Cabrera, M., Shaw, M-A., Sharples, C., Williams, H., Castes, M., Convit, J. and Blackwell, J.M. (1995). Polymorphism in TNF genes associated with mucocutaneous leishmaniasis. Journal of Experimental Medicine, 182, 1259-1264. PubMed

Espinoza, J., Skinner, A.C., Davies, C., Lluanos-Cuentas, A., Arevalo, J., Dye, C., McMaster, W.R., Ajioka, J.W. and Blackwell, J.M. (1995) Extensive polymorphism at the Gp63 locus in field isolates of Leishmania peruviana. Molecular and Biochemical Parasitology, 72, 203-213. PubMed

Levin, M., Newport, M.J., D'Souza, S., Kalabalikis, P., Brown, I.N., Lenicker, H.M., Agius, P.V., Davies, E.G., Thrasher, A. and Blackwell, J.M. (1995). Familial disseminated atypical mycobacterial infection in early childhood: a human mycobacterial susceptibility gene? Lancet, 345, 79-83. PubMed

Newport, M., Levin, M., Blackwell, J., Shaw, M-A., Williamson, R. and Huxley, C. (1995) Evidence for exclusion of a mutation in NRAMP as the cause of familial disseminated atypical mycobacterial infection in a Maltese kindred. Journal of Medical Genetics, 32, 904-906. PubMed

Roach, T.I.A., Chatterjee, D., Liew, F.Y. and Blackwell, J.M. (1995) Opposing effects of interferon-g on iNOS and IL-10 expression in LPS and mycobacterial LAM stimulated macrophages. Immunology, 85, 106-113. PubMed

Reviews
Blackwell, J.M., Jiang, H. and White, J.K. (2004) Role of Nramp family in pro-inflammatory diseases. In: Cellier, M. and Gros, P. (editors) The Nramp Family. Landes Bioscience, ISBN: 0-306-47841-2, http://www.eurekah.com.

Blackwell, J.M., Mohamed, H.S. and Ibrahim, M.E. (2004) Genetics and visceral leishmaniasis in The Sudan: Seeking a link. Trends in Parasitology, 20, 268-74.PubMed

Blackwell, J.M., Searle, S., Mohamed, H. and White, J.K. (2003) Divalent cation transport and susceptibility to infectious and autoimmune diseases: Continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story. Immunology Letters, 85,197-203.PubMed

Blackwell, J.M. (2001) Modern genetics and leprosy susceptibility. Leprosy Reviews, 72,352-356.PubMed

Almeida, R., Norrish, A., Levick, M., Vetrie, D., Freeman, T., Ivens, A., lange, U., Stober, C., McCann, S. and Blackwell, J.M. (2001) From genomes to vaccines: Leishmania as a model. Philosophical Transactions of the Royal Society B, (1417):5-11. PubMed

Blackwell, J.M. (2001) Genetics and genomics in the study of susceptibility to infectious disease. Trends in Molecular Medicine, 7, 521-526.PubMed

Blackwell, J.M., Goswami, T., Evans, C., Sibthorpe, D., Papo, N., White, J.K., Searle, S., Miller, E.N., Peacock, C.S., Mohammed, H., and Ibrahim, M. (2001) SLC11A1 (formerly NRAMP1) and disease resistance. Cellular Microbiology, (12):773-84PubMed

Blackwell, J.M., Searle, S., Goswami, T. and Miller, E.N. (2000) Understanding the multiple functions of Nramp1. Microbes and Infection, 2, 317-321. PubMed

Blackwell, J.M. and Searle, S. (1999) Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg). Immunology Letters, 65, 73-80. PubMed

Blackwell, J.M., Black, G.F., Sharples, C., Soo, S-S., Peacock, C.S. and Miller, E.N. (1999) Roles of Nramp1, HLA, and a gene(s) in allelic association with IL4, in determining T helper subset differentiation. Microbes and Infection, 1, 95-102. PubMed

Blackwell, J.M. and Melville, S.E. (1999) Status of protozoan genome analysis: Trypanosomatids. Parasitology, 118, S11-S14. PubMed

Blackwell, J.M. (1997) Protozoan Parasite Genome Analysis: Progress in the African trypanosome and leishmanial genome networks. Transactions of the Royal Society of Tropical Medicine and Hygiene, 91, 107-110. PubMed

Newport, M.J. and Blackwell, J.M. (1997) Genetic susceptibility to tuberculosis. Bailliere's Clinical Infectious Disease: Mycobacterial Disease 4, 207-230.

Blackwell, J.M. (1998) Genetic susceptibility to intramacrophage pathogens: A family study of leishmaniasis, leprosy and tuberculosis in Brazil. International Journal of Parasitology, 28, 21-28. PubMed

Blackwell, J.M. (1996) The natural resistance associated macrophage protein (NRAMP1): relating structure to regulation of macrophage activation. Molecular Medicine Today, 2, 205-211. PubMed

Blackwell, J.M. (1996) Genetic susceptibility to leishmanial infections: studies in mice and man. Parasitology, 112, S67-S74. PubMed

Ivens, A.C. and Blackwell, J.M. (1996) Unravelling the Leishmania genome. Current Opinion in Genetics and Development, 6, 704-710. PubMed
Projects:-
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Last updated on the 2nd November 2005
Maintained by Richard Francis.